From Business: Enjoy a comfortable stay at the newest hotel in Sikeston, MO. We are conveniently located off Highway 60 and Interstate 55, very close to historic downtown and a short walk to…

From Business: Our brand-new hotel in Sikeston, MO is conveniently located off Highway 60 and Interstate 55, very close to historic downtown and a short walk to a variety of shops and…

From Business: Settle in for a relaxing stay at the Sikeston’s newest hotel. Our Hampton Inn Sikeston hotel is located off Highway 60 and Interstate 55, just minutes from historic downtown…

From Business: Days Inn is a provider of hospitality services and accommodation facility. Based in Sikeston, Mo., it offers daybreak breakfast items, such as Minute Maid juices, Kellogg's…

From Business: The Pear Tree Inn Sikeston is conveniently located off I-55 in Sikeston near shopping and dining at local legend Lambert’s Café. Sikeston is halfway between St. Louis and…

From Business: Drury Inn & Suites is conveniently located off I-55 in Sikeston near local legend Lambert’s Café. Sikeston is halfway between St. Louis and Memphis in the Missouri Bootheel,…

From Business: IHG Rewards Club Members: Get better savings with YOUR RATE. Book hotels direct at holidayinnexpress.com for our lowest rates. You won't find these anywhere else. Large…

From Business: See why so many travelers make Comfort Inn & Suites Sikeston their hotel of choice when visiting Sikeston. Providing an ideal mix of value, comfort and convenience, it offers a…

"It was my first time staying at a Best Western and I enjoyed it. I was suprised to see how much space we had in our room. But, it was a good amount of space for the cost of the…"

From Business: Motel 6 Sikeston is an excellent choice for travelers visiting Sikeston, offering a budget friendly environment alongside many helpful amenities designed to enhance your stay.…