"One of the nicest mid-range hotels I've have stayed at. Great staff, beautiful lobby and rooms. Will be back next time."

From Business: Located directly off I-55, Drury Suites Cape Girardeau is the perfect stop for business or leisure travelers. At the heart of Cape Girardeau, the hotel is just minutes away…

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From Business: Best Western Plus Jackson/Cape Girardeau hotel in Jackson, Missouri! Our hotel is located just off I-55 at Exit 99. This hotel offers 80 rooms including 9 suites.Best Western…

From Business: Travel Happy® with Drury Hotels. You have enough to worry about while you're traveling. Let us take a few things off your plate, so you can focus on the good stuff. Breakfast,…

From Business: Comfort Suites in Jackson Missouri is an all suite property located on the edge of Cape Girardeau and Jackson Missouri. We offer an indoor pool/hot tub, fitness center, guest…

From Business: The Fairfield Inn and Suites is Cape Girardeau's newest property by Marriott that features a saltwater pool, fitness center and a free hot breakfast to fuel up your stay. Relax…

From Business: Whether traveling for business or fun, Courtyard by Marriott® makes all your travels successful by providing what you need: spacious, thoughtful guest rooms and services that…

From Business: From our daily free hot breakfast to our nightly cookie hour, Hampton Inn Cape Girardeau I-55 East makes you feel at home. Located on the southeast corner of I-55 and William…

From Business: Drury Inn & Suites is conveniently located off I-55 in Sikeston near local legend Lambert’s Café. Sikeston is halfway between St. Louis and Memphis in the Missouri Bootheel,…

From Business: The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. The Econo Lodge hotel in…

From Business: Get a great start to your day at the Comfort Inn Poplar Bluff, MO hotel. Enjoy the friendly service and signature hot breakfast at our smoke - free hotel. We have cozy rooms…

From Business: Newest hotel in Poplar Bluff offering beautiful guest rooms with home-inspired decor. Rooms have either one or two queen sized beds. All rooms have a refrigerator, flat screen…

From Business: Welcome to Travelodge by Wyndham Dexter, your Dexter “home away from home.”Travelodge by Wyndham Dexter aims to make your visit as relaxing and enjoyable as possible, which is…

From Business: Poplar Bluff is a southeast Missouri town in the Ozark Foothills, located on the Black River near conservation and recreation areas perfect for boating, hunting, fishing and…

From Business: Days Inn is a provider of hospitality services and accommodation facility. Based in Sikeston, Mo., it offers daybreak breakfast items, such as Minute Maid juices, Kellogg's…

"It was my first time staying at a Best Western and I enjoyed it. I was suprised to see how much space we had in our room. But, it was a good amount of space for the cost of the…"

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From Business: See why so many travelers make Comfort Inn & Suites Sikeston their hotel of choice when visiting Sikeston. Providing an ideal mix of value, comfort and convenience, it offers a…