"One of the nicest mid-range hotels I've have stayed at. Great staff, beautiful lobby and rooms. Will be back next time."

From Business: Located directly off I-55, Drury Suites Cape Girardeau is the perfect stop for business or leisure travelers. At the heart of Cape Girardeau, the hotel is just minutes away…

From Business: This Bavarian-style hotel off I-55 in Jackson may not look like the other Drury Inn & Suites on the outside, but our friendly staff always welcomes guests to relax in a clean,…

From Business: The St. Genevieve, MO Econo Lodge hotel is off Interstate 55, near all the historical, small-town highlights of Ste. Genevieve, while being a short drive from St. Louis. We…

From Business: From our daily free hot breakfast to our nightly cookie hour, Hampton Inn Cape Girardeau I-55 East makes you feel at home. Located on the southeast corner of I-55 and William…

From Business: Whether you are visiting Missouri for business or pleasure, our Days Inn Perryville hotel has something to offer everyone. Located off I-55 near the Perry County Community Lake…

From Business: Whether traveling for business or fun, Courtyard by Marriott® makes all your travels successful by providing what you need: spacious, thoughtful guest rooms and services that…

From Business: The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Get more of the space you…

From Business: Travel Happy® with Drury Hotels. You have enough to worry about while you're traveling. Let us take a few things off your plate, so you can focus on the good stuff. Breakfast,…

From Business: IHG Rewards Club Members: Get better savings with YOUR RATE. Book hotels direct at candlewoodsuites.com for our lowest rates. You won't find these anywhere else. Experience…

From Business: Willow House B&B is a historically restored Victorian home, just two blocks off the main square in Perryville, Missouri. A quite and peaceful B&B located next to willow pond…

From Business: Best Western Plus Jackson/Cape Girardeau hotel in Jackson, Missouri! Our hotel is located just off I-55 at Exit 99. This hotel offers 80 rooms including 9 suites.Best Western…

From Business: The Fairfield Inn and Suites is Cape Girardeau's newest property by Marriott that features a saltwater pool, fitness center and a free hot breakfast to fuel up your stay. Relax…

From Business: This southern Illinois getaway is part of an extension to OUR existing lodging the Davie INN. We have been in the lodging business for 12 years NOW and are happy to ADD a cabin…

From Business: Looking for a place to stay in Fredericktown? Then look no further than Madison Inn Lodge, a motel that brings the best of Fredericktown to your doorstep. Rooms at Madison Inn…

From Business: Nestled in the rolling hills of the Shawnee National Forest and surrounded by award winning wineries this budget motel is conveniently located within easy reach of Lincoln…

From Business: about us Our cabins feature one of the most spectacular views in Southern Illinois. Sit on the porch and enjoy the abundant wildlife and sounds of nature. Each cabin includes a…